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research in the biochemistry and molecular biology of lipids and lipoproteins has experienced a remarkable rebirth within the past few years with the realization that lipids play important roles not only in membrane structure and the functioning of membrane proteins, but also in diseases such as heart disease, diabetes, obesity, stroke, cancer and neurological diseases. In addition, lipids are known to participate widely in signaling pathways which impact on all basic biological processes. The 4th edition has been written with two major objectives in mind. The first is to provide students and teachers with an advanced and up-to-date textbook covering the major areas in the fields of lipid, lipoprotein and membrane biochemistry and molecular biology. The second objective of this book is to satisfy the need for a general reference and review book for scientists studying lipids, lipoproteins and membranes. This book remains unique in that it is not a collection of exhaustive reviews on the various topics, but rather is a current, readable and critical summary of these areas of research. This book should allow scientists to become familiar with recent discoveries related to their own research interests, and should also help clinical researchers and medical students keep abreast of developments in basic science that are important for clinical advances in the future. Excellent up-to-date reviews are available on all the topics included in this book and many of these reviews are cited in the relevant chapters. Chapters in this books are: Functional roles of lipids in membranes; Lipid Modification of Proteins; Fatty acid and phospholipid metabolism in prokaryotes; Lipid metabolism in plants; Oxidation on fatty acid in eukaryotes; Fatty acid synthesis in eukaryotes; Fatty acid desaturation and chain elongation in eukaryotes; Phospholipid biosynthesis in eukaryotes; Ether-linked lipids and their bioactive species; Adipose tissue and lipid metabolism; Phospholipases; Glycerolipids in signal transduction; the eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase; Sphingolipids: metabolism and cell signaling; cholesterol biosynthesis; Metabolism and function of bile acids; Lipid assembly into cell membranes; Lipoprotein structure; Assembly and secretion of lipoproteins; Dynamics of lipoprotein transport in the human circulatory system; and Lipoprotein receptors.