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Biochemistry is rapidly progressing from a science performed almost entirely at the laboratory bench to one that may be explored through computers. The recently developed ability to determine entire genomic sequences has provided the data needed to accomplish massive comparisons of derived protein sequences, the results of which may be used to formulate and test hypotheses about biochemical function. The power of these new methods is explained by the impact of evolution: many molecules and biochemical pathways have been generated by duplicating and modifying existing ones Part 1,The Molecular Design of Life, introduces the most important classes of biological macromolecules, including proteins, nucleic acids, carbohydrates, and lipids, and presents the basic concepts of catalysis and enzyme action. Part 2, Transducing and Storing Energy, examines pathways for the interconversion of different forms of energy. Part 3, Synthesizing the Molecules of Life, focuses on the synthesis of biological macromolecules and their components. Part 4, Responding to Environmental Changes, looks at how cells sense and adapt to changes in their environments.